This is not always the case and a person may continue to suffer even long after the drug has been stopped. Sometimes, the adverse effects disappear when the medication is stopped. It is not uncommon that a person will stop drug therapy altogether, due to not liking the adverse effects. This scenario can become quite complex as a person may be switched from one drug to another, and then prescribed additional drugs to counteract emerging adverse reactions. Patients who do not respond to antidepressants are referred to as “treatment-resistant.” Treatment-resistive depression has the ominous sound of being another type of disorder and may leave a person feeling confused and desperate for help. Later independent studies and case history information has provided more information over time.Ībout half the people who start antidepressants do not respond favorably, and it is quite common to be switched to another drug, in trial-and-error fashion. This is not uncommon in the fast-paced world of drug manufacturing. Before approval, the drug was only tested in very short drug trials. No information appears on the drug label concerning the long-term effects of Wellbutrin. What Are the Long-term Effects of Wellbutrin? Off-label uses are diverse and include alleviating drug-induced sexual dysfunction, as well as ADHD, obesity, depressive episodes of BiPolar, anxiety, Dysthymic disorder, PTSD, social phobias, neuropathic pain, and many others. After expanding the black-box warning to include the risk of seizures (AKA neuropsychiatric symptoms), the drug was re-launched in 1989. Shortly after the drug was first brought to market, it had to be withdrawn due to a reported increase in the onset of seizures. For all uses, the drug carries a black-box warning cautioning against risks of suicide, and unspecified “neuropsychiatric” symptoms. The FDA approved Wellbutrin for MDD (major depressive disorders), seasonal affective disorder, and for smoking cessation - usually prescribed under a different brand name, Zyban©. Drugs like Wellbutrin can have varying effects on different people, and over time, can have unpredictable and changing outcomes and negative long-term effects. But drug regulators and drugmakers clearly note that the exact mechanisms of action are unknown. The concentration of naturally produced neurochemicals is proffered as a way to positively influence depressed mood and many other mental and physical factors. Both norepinephrine (a form of adrenaline) and dopamine (the “reward” chemical) are activating or excitatory neurochemicals. This blockage in transmission creates a build-up of neurochemicals. One might compare this to a roadblock along a highway. The drug binds to or blocks receptors of these natural chemicals. Antidepressants do not add or create more of these vital neurochemicals. Wellbutrin affects the transmission of norepinephrine and dopamine, but despite suggestive advertising, it does not function as a vitamin supplement. NDRI is is an acronym for the 2 main neurochemicals that it targets, and the reuptake-inhibiting mechanism that the drug imposes on the transmission of these natural chemicals throughout the nervous system.
The antidepressant Wellbutrin (first approved in 1986) is classed as an NDRI.
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